Which of the following diseases is characterized by an aculation of phenylalanine in the body?

I am not sure about the second question, but the first question is B. PKU. Phenylketonuria (PKU) is caused by a mutation on chromosome 12. The enzyme phenylalanine hydroxylase (PAH) is used to convert phenylalanine into tyrosine, but in those who have PKU phenylalanine hydroxylase is either missing or deficient. Because phenylalanine cannot be converted into tyrosine it simply builds up in the body.